Publications

2023


Wethekam LC, Moore JK. α-tubulin regulation by 5' introns in S. cerevisiae. Genetics. 2023 Sep 7. PMID: 37675603

Wethekam LC, Moore JK.Tubulin isotype regulation maintains asymmetric requirement for α-tubulin over β-tubulin. J Cell Biol. 2023 Mar 6.PMID: 36719400

2022

Hoff KJ, Neumann AJ, Moore JK. The molecular biology of tubulinopathies: Understanding the impact of variants on tubulin structure and microtubule regulation. Front Cell Neurosci. 2022 Nov 2;16. PMID: 36406756 

Wethekam LC, Moore JK .Microtubule cytoskeleton: Revealing new readers of the tubulin code. Curr Biol. 2022 Sep 26;32(18). PMID: 36167046 

​Hoff KJ, Aiken JE, Gutierrez MA, Franco SJ, Moore JK. TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics. Elife. 2022 May 5.PMID: 35511030

2021


​Park K, Hoff KJ, Wethekam L, Stence N, Saenz M, Moore JK. Kinetically stabilizing mutations in beta tubulins create isotype-specific brain malformations. Front Cell Dev Biol. 2021 Nov 18. PMID: 34869359 

​Moore JK, Wethekam L. Specialist alpha-tubulins for pluralist microtubules. J Cell Biol. 2021 Dec 6;220(12). PMID: 34762120

​Zhang G, Dong Z, Gimple RC, Wolin A, Wu Q, Qiu Z, Wood LM, Shen JZ, Jiang L, Zhao L, Lv D, Prager BC, Kim LJY, Wang X, Zhang L, Anderson RL, Moore JK, Bao S, Keller TH, Lin G, Kang C, Hamerlik P, Zhao R, Ford HL, Rich JN. Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe. J Exp Med. 2021 Nov 1;218(11). PMID: 34617969

2020

Thomas EC, Ismael A, Moore, JK. Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone. Mol Biol Cell. 2020 Nov 15; 31(24):2733. PMID: 32997572
Gudimchuk NB, Ulyanov EV, O'Toole E, Page CL, Vinogradov DS, Morgan G, Li G, Moore JK, Szczesna E, Roll-Mecak A, Ataullakhanov FI, Richard McIntosh J. Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography. Nat Commun. 2020 Jul 28;11(1):3765. PMID: 32724196
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Li G, Moore JK. 
Microtubule dynamics at low temperature: evidence that tubulin recycling limits assembly. 
Mol Biol Cell. 2020 May 15;31(11):1154-1166. PMID: 32213119.
Aiken J, Buscaglia G, Aiken AS, Moore JK, Bates EA. 
Tubulin mutations in brain development disorders: Why haploinsufficiency does not explain TUBA1A tubulinopathies. 
Cytoskeleton . 2020 Mar;77(3-4):40-54.PMID: 31574570.

2019

​Estrem C, and JK Moore.
Help or Hindrance: How do microtubule-based forces contribute to genome damage and repair?
Curr Genet. 2019 Sep 9. PMID: 31501990

​Estrem C, Moore JK.
​Astral microtubule forces alter nuclear organization and inhibit DNA repair in budding yeast.
Mol Biol Cell. 2019 Jul 22;30(16):2000-2013. PMID: 31067146
Fees CP and JK Moore.
A unified model for microtubule rescue
Mol Biol Cell. 2019 Mar 15;30(6):753-765. PMID: 30672721
Aiken J, Moore JK, and EA Bates.
TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity.
Hum Mol Genet. 2019 Apr 15;28(8):1227-1243. PMID:30517687

2018
Fees CP and JK Moore.  
Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulin.
​Life Science Alliance. PMID:29963657

2017
​Aiken J, Buscaglia G, Bates EA, and JK Moore. 
The alpha-tubulin gene TUBA1A in brain development: A key ingredient in the neuronal isotype blend. J Dev Biol. 5:3.  ​​​PMID:29057214
​Estrem C, Fees CP, and JK Moore.
Dynein is regulated by the stability of its microtubule track. JCB. 216:7. ​PMID:28572117
 
http://www.jove.com/video/55610
​Fees CP, Estrem C, and JK Moore.
​High-resolution imaging and analysis of of individual astral microtubule dynamics in budding yeast. JoVE. 122. 

2016
Mangan AJ, Sietsema DV, Li D, Moore JK, Citi S, and R Prekeris.  
Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells. Nature Comms. 7:12426.  ​PMID: 27484926
Fees CP, Aiken J, O'Toole ET, Giddings TH Jr, and JK Moore.  
The negatively-charged carboxy-terminal tail of β-tubulin promotes proper chromosome segregation. MBoC.  ​PMID: 270536622

2015
Hanson MG, Aiken J, Sietsema DV, Bates E, Sept D, Niswander L, and JK Moore.  
Novel α-tubulin mutation disrupts neural development and tubulin proteostasis. Dev Biol. 15:30198-6. PMID: 26658218
Nithiananatham S, Le S, Seto E, Jia W, Leary J, Corbett KD, Moore JK, and J Al-Bassam.  
Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. Elife. 4. PMID: 26208336

2014
Aiken J, Sept D, Costanzo M, Boone C, Cooper JA, and JK Moore.  
Genome-wide Analysis Reveals Novel and Discrete Functions for Tubulin Carboxy-terminal Tails. Curr Biol. 24:1295-1303. PMID: 24835459  

2013
JK Moore.  
Stopped in its tracks: negative regulation of the dynein motor by the yeast protein She1. Bioessays.35:677-82. PMID: 23666903
Siglin AE, Sun S, Moore JK, Tan S, Poenie M, Lear JD, Polenova T, Cooper JA, and JC Williams. 
Dynein and Dynactin Leverage their Bivalent Character to form a High-Affinity Interaction. PLoS One. 8(4):e59453. PMID: 23577064

2011

Stuchell-Brereton MD, Siglin A, Li J, Moore JK, Ahmed S, Williams JC, Cooper JA. Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Mol Biol Cell. 2011 Aug 1;22(15):2690-701.  PMID: 21633107

2010

Moore JK, Chudalayandi P, Heil-Chapdelaine RA, Cooper JA. 
The spindle position checkpoint is coordinated by the Elm1 kinase. J Cell Biol. 2010 Nov 1;191(3):493-503. PubMed PMID: 21041444
Moore JK, Cooper JA. 
Coordinating mitosis with cell polarity: Molecular motors at the cell cortex. Semin Cell Dev Biol. 2010 May;21(3):283-9.PMID: 20109571

2009

Moore JK, Magidson V, Khodjakov A, Cooper JA. 
The spindle position checkpoint requires positional feedback from cytoplasmic microtubules. Curr Biol. 2009 Dec 15;19(23):2026-30. PMID: 19913426
Moore JK, Stuchell-Brereton MD, Cooper JA. 
Function of dynein in budding yeast: mitotic spindle positioning in a polarized cell.Cell Motil Cytoskeleton. 2009 Aug;66(8):546-55.  PMID: 19402153

Moore JK, Sept D, Cooper JA. 
Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5147-52.PMID: 19279216

2008

Moore JK, Li J, Cooper JA. 
Dynactin function in mitotic spindle positioning. Traffic. 2008 Apr;9(4):510-27.  PMID: 18221362
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